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Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells

Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major histocompatibility complex class I (MHC-I)-restricted T cells. Optimal positive selection of CD8(+) T cells requires cortical thymic epithelial cells th...

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Detalles Bibliográficos
Autores principales:	Sasaki, Katsuhiro, Takada, Kensuke, Ohte, Yuki, Kondo, Hiroyuki, Sorimachi, Hiroyuki, Tanaka, Keiji, Takahama, Yousuke, Murata, Shigeo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557289/ https://www.ncbi.nlm.nih.gov/pubmed/26099460 http://dx.doi.org/10.1038/ncomms8484

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