Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain

BACKGROUND: TAR DNA-binding protein 43 (TDP-43) is a nuclear protein, but it is redistributed in the neuronal cytoplasm in both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Because small transgenic animal models often lack cytoplasmic TDP-43, how the cytoplasmic...

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Detalles Bibliográficos
Autores principales: Wang, Guohao, Yang, Huaqiang, Yan, Sen, Wang, Chuan-En, Liu, Xudong, Zhao, Bentian, Ouyang, Zhen, Yin, Peng, Liu, Zhaoming, Zhao, Yu, Liu, Tao, Fan, Nana, Guo, Lin, Li, Shihua, Li, Xiao-Jiang, Lai, Liangxue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557629/
https://www.ncbi.nlm.nih.gov/pubmed/26334913
http://dx.doi.org/10.1186/s13024-015-0036-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557629/
https://www.ncbi.nlm.nih.gov/pubmed/26334913
http://dx.doi.org/10.1186/s13024-015-0036-5

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