Effect of rAd5-Vector HIV-1 Preventive Vaccines on HIV-1 Acquisition: A Participant-Level Meta-Analysis of Randomized Trials

BACKGROUND: Three phase 2b, double-blind, placebo-controlled, randomized efficacy trials have tested recombinant Adenovirus serotype-5 (rAd5)-vector preventive HIV-1 vaccines: MRKAd5 HIV-1 gag/pol/nef in Step and Phambili, and DNA/rAd5 HIV-1 env/gag/pol in HVTN505. Due to efficacy futility observed...

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Detalles Bibliográficos
Autores principales: Huang, Yunda, Follmann, Dean, Nason, Martha, Zhang, Lily, Huang, Ying, Mehrotra, Devan V., Moodie, Zoe, Metch, Barbara, Janes, Holly, Keefer, Michael C., Churchyard, Gavin, Robb, Merlin L., Fast, Patricia E., Duerr, Ann, McElrath, M. Juliana, Corey, Lawrence, Mascola, John R., Graham, Barney S., Sobieszczyk, Magdalena E., Kublin, James G., Robertson, Michael, Hammer, Scott M., Gray, Glenda E., Buchbinder, Susan P., Gilbert, Peter B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558095/
https://www.ncbi.nlm.nih.gov/pubmed/26332672
http://dx.doi.org/10.1371/journal.pone.0136626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558095/
https://www.ncbi.nlm.nih.gov/pubmed/26332672
http://dx.doi.org/10.1371/journal.pone.0136626

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