KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models

Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. Because of a high rate of immunoglobulin synthesis, the endoplasmic reticulum of MM cells is subjected to elevated basal levels of stress. Consequently, proteasome inhibitors, which exacerbate this stress by inhibiting ubiquitin-pr...

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Detalles Bibliográficos
Autores principales: Riz, Irene, Hawley, Teresa S., Hawley, Robert G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558117/
https://www.ncbi.nlm.nih.gov/pubmed/26109433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558117/
https://www.ncbi.nlm.nih.gov/pubmed/26109433

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