DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma

Glaucoma is the leading cause of irreversible blindness and is characterized by slow and progressive degeneration of the optic nerve head axons and retinal ganglion cell (RGC), leading to loss of visual function. Although oxidative stress and/or alteration of mitochondrial (mt) dynamics induced by e...

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Detalles Bibliográficos
Autores principales: Kim, K-Y, Perkins, G A, Shim, M S, Bushong, E, Alcasid, N, Ju, S, Ellisman, M H, Weinreb, R N, Ju, W-K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558491/
https://www.ncbi.nlm.nih.gov/pubmed/26247724
http://dx.doi.org/10.1038/cddis.2015.180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558491/
https://www.ncbi.nlm.nih.gov/pubmed/26247724
http://dx.doi.org/10.1038/cddis.2015.180

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