Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification

The ATM-p53 DNA-damage response (DDR) pathway has a crucial role in chemoresistance in CLL, as indicated by the adverse prognostic impact of genetic aberrations of TP53 and ATM. Identifying and distinguishing TP53 and ATM functional defects has become relevant as epigenetic and posttranscriptional d...

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Detalles Bibliográficos
Autores principales: te Raa, G D, Moerland, P D, Leeksma, A C, Derks, I A, Yigittop, H, Laddach, N, Loden-van Straaten, M, Navrkalova, V, Trbusek, M, Luijks, D M, Zenz, T, Skowronska, A, Hoogendoorn, M, Stankovic, T, van Oers, M H, Eldering, E, Kater, A P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558513/
https://www.ncbi.nlm.nih.gov/pubmed/26247737
http://dx.doi.org/10.1038/cddis.2015.223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558513/
https://www.ncbi.nlm.nih.gov/pubmed/26247737
http://dx.doi.org/10.1038/cddis.2015.223

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