Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury

Excitotoxicity following cerebral ischemia elicits a molecular cascade, which leads to neuronal death. c-Jun-N-terminal kinase (JNK) has a key role in excitotoxic cell death. We have previously shown that JNK inhibition by a specific cell-permeable peptide significantly reduces infarct size and neur...

Descripción completa

Detalles Bibliográficos
Autores principales: Vercelli, A, Biggi, S, Sclip, A, Repetto, I E, Cimini, S, Falleroni, F, Tomasi, S, Monti, R, Tonna, N, Morelli, F, Grande, V, Stravalaci, M, Biasini, E, Marin, O, Bianco, F, di Marino, D, Borsello, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558515/
https://www.ncbi.nlm.nih.gov/pubmed/26270349
http://dx.doi.org/10.1038/cddis.2015.226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558515/
https://www.ncbi.nlm.nih.gov/pubmed/26270349
http://dx.doi.org/10.1038/cddis.2015.226

Ejemplares similares