Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity

All-trans retinoic acid (ATRA), a pan-retinoic acid receptor (RAR) agonist, is, along with other retinoids, a promising therapeutic agent for the treatment of a variety of solid tumors. On the one hand, preclinical studies have shown promising anticancer effects of ATRA in breast cancer; on the othe...

Descripción completa

Detalles Bibliográficos
Autores principales: Brigger, D, Schläfli, A M, Garattini, E, Tschan, M P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558517/
https://www.ncbi.nlm.nih.gov/pubmed/26313912
http://dx.doi.org/10.1038/cddis.2015.236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558517/
https://www.ncbi.nlm.nih.gov/pubmed/26313912
http://dx.doi.org/10.1038/cddis.2015.236

Ejemplares similares