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Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars

Iminosugars have attracted increasing attention as chemical probes, chaperones and leads for drug discovery. Despite several clinical successes, their de novo synthesis remains a significant challenge that also limits their integration with modern high-throughput screening technologies. Herein, we d...

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Detalles Bibliográficos
Autores principales: Bergeron-Brlek, Milan, Meanwell, Michael, Britton, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558570/
https://www.ncbi.nlm.nih.gov/pubmed/25903019
http://dx.doi.org/10.1038/ncomms7903