A hypoxic ticket to the bone metastatic niche

Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading to the formation of pre-metastatic niches that can later foster metastat...

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Detalles Bibliográficos
Autor principal: Vanharanta, Sakari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558777/
https://www.ncbi.nlm.nih.gov/pubmed/26337273
http://dx.doi.org/10.1186/s13058-015-0635-7
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author Vanharanta, Sakari
author_facet Vanharanta, Sakari
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description Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading to the formation of pre-metastatic niches that can later foster metastatic colonization in distant organs. Recent findings have demonstrated that such niches can also form in the bone, possibly revealing new avenues for therapeutic intervention.
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spelling pubmed-45587772015-09-04 A hypoxic ticket to the bone metastatic niche Vanharanta, Sakari Breast Cancer Res Viewpoint Hypoxia is a well-characterized driver of aggressive cancer phenotypes, including metastasis. Accumulating evidence suggests that, in addition to having local effects, the consequences of tumour hypoxia can be systemic, leading to the formation of pre-metastatic niches that can later foster metastatic colonization in distant organs. Recent findings have demonstrated that such niches can also form in the bone, possibly revealing new avenues for therapeutic intervention. BioMed Central 2015-09-04 2015 /pmc/articles/PMC4558777/ /pubmed/26337273 http://dx.doi.org/10.1186/s13058-015-0635-7 Text en © Vanharanta. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Viewpoint
Vanharanta, Sakari
A hypoxic ticket to the bone metastatic niche
title A hypoxic ticket to the bone metastatic niche
title_full A hypoxic ticket to the bone metastatic niche
title_fullStr A hypoxic ticket to the bone metastatic niche
title_full_unstemmed A hypoxic ticket to the bone metastatic niche
title_short A hypoxic ticket to the bone metastatic niche
title_sort hypoxic ticket to the bone metastatic niche
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558777/
https://www.ncbi.nlm.nih.gov/pubmed/26337273
http://dx.doi.org/10.1186/s13058-015-0635-7
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