5’-adenosine monophosphate mediated cooling treatment enhances ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) stability in vivo

BACKGROUND: Gene mutations that produce misprocessed proteins are linked to many human disorders. Interestingly, some misprocessed proteins retained their biological function when stabilized by low temperature treatment of cultured cells in vitro. Here we investigate whether low temperature treatmen...

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Detalles Bibliográficos
Autores principales: Zhang, Yueqiang, O’Brien, William G., Zhao, Zhaoyang, Lee, Cheng Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559075/
https://www.ncbi.nlm.nih.gov/pubmed/26335336
http://dx.doi.org/10.1186/s12929-015-0178-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559075/
https://www.ncbi.nlm.nih.gov/pubmed/26335336
http://dx.doi.org/10.1186/s12929-015-0178-3

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