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5’-adenosine monophosphate mediated cooling treatment enhances ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) stability in vivo
BACKGROUND: Gene mutations that produce misprocessed proteins are linked to many human disorders. Interestingly, some misprocessed proteins retained their biological function when stabilized by low temperature treatment of cultured cells in vitro. Here we investigate whether low temperature treatmen...
Autores principales: | Zhang, Yueqiang, O’Brien, William G., Zhao, Zhaoyang, Lee, Cheng Chi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559075/ https://www.ncbi.nlm.nih.gov/pubmed/26335336 http://dx.doi.org/10.1186/s12929-015-0178-3 |
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