A Physiologically Based Pharmacokinetic Drug–Disease Model to Predict Carvedilol Exposure in Adult and Paediatric Heart Failure Patients by Incorporating Pathophysiological Changes in Hepatic and Renal Blood Flows

BACKGROUND AND OBJECTIVE: Chronic diseases are associated with pathophysiological changes that could have profound impacts on drug pharmacokinetic behaviour, with a potential need to modify the administered drug therapy. It is important to acknowledge that most patients with chronic illnesses do not...

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Detalles Bibliográficos
Autores principales: Rasool, Muhammad Fawad, Khalil, Feras, Läer, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559583/
https://www.ncbi.nlm.nih.gov/pubmed/25773479
http://dx.doi.org/10.1007/s40262-015-0253-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559583/
https://www.ncbi.nlm.nih.gov/pubmed/25773479
http://dx.doi.org/10.1007/s40262-015-0253-7

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