Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function

The most aggressive tumour cells, which often reside in hypoxic environments, rely on glycolysis for energy production. Thereby they release vast amounts of lactate and protons via monocarboxylate transporters (MCTs), which exacerbates extracellular acidification and supports the formation of a host...

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Detalles Bibliográficos
Autores principales: Jamali, Somayeh, Klier, Michael, Ames, Samantha, Felipe Barros, L., McKenna, Robert, Deitmer, Joachim W., Becker, Holger M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559800/
https://www.ncbi.nlm.nih.gov/pubmed/26337752
http://dx.doi.org/10.1038/srep13605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559800/
https://www.ncbi.nlm.nih.gov/pubmed/26337752
http://dx.doi.org/10.1038/srep13605

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