A Bayesian adaptive design for biomarker trials with linked treatments

BACKGROUND: Response to treatments is highly heterogeneous in cancer. Increased availability of biomarkers and targeted treatments has led to the need for trial designs that efficiently test new treatments in biomarker-stratified patient subgroups. METHODS: We propose a novel Bayesian adaptive rando...

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Detalles Bibliográficos
Autores principales: Wason, James M S, Abraham, Jean E, Baird, Richard D, Gournaris, Ioannis, Vallier, Anne-Laure, Brenton, James D, Earl, Helena M, Mander, Adrian P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559835/
https://www.ncbi.nlm.nih.gov/pubmed/26263479
http://dx.doi.org/10.1038/bjc.2015.278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559835/
https://www.ncbi.nlm.nih.gov/pubmed/26263479
http://dx.doi.org/10.1038/bjc.2015.278

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