Cargando…

Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo

BACKGROUND: Colorectal cancer (CRC) is a major health problem in China and around the world. It is one of the leading causes of cancer-related deaths. Research groups are thus searching for novel and more efficient anti-CRC agents. RESULTS: Here we demonstrated that ABC294640, a novel SphK2 inhibito...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xun, Cai, Chen, Min-Bin, Qi, Li, Tie-Ning, Zhang, Peng, Xue, Ning, Li, Zhi-Xiao, Chen, Li-Wei, Wang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559903/ https://www.ncbi.nlm.nih.gov/pubmed/26337959 http://dx.doi.org/10.1186/s13046-015-0205-y

Ejemplares similares

Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget
por: Hatoum, Diana, et al.
Publicado: (2017)

Sphingosine Kinase-1 (SphK-1) Regulates Mycobacterium smegmatis Infection in Macrophages
por: Prakash, Hridayesh, et al.
Publicado: (2010)

The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth
por: Xu, Ling, et al.
Publicado: (2017)

Sphingosine kinase 2 inhibitor ABC294640 displays anti-epithelial ovarian cancer activities in vitro and in vivo
por: Song, Keqi, et al.
Publicado: (2019)

Targeting Sphingosine Kinase by ABC294640 against Diffuse Intrinsic Pontine Glioma (DIPG)
por: Dai, Lu, et al.
Publicado: (2020)

Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells
por: Lu, Pei-Hua, et al.
Publicado: (2017)

Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640
por: Lewis, Clayton S., et al.
Publicado: (2016)

Therapeutic Potential of SphK1 Inhibitors Based on Abnormal Expression of SphK1 in Inflammatory Immune Related-Diseases
por: Bu, Yanhong, et al.
Publicado: (2021)

Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells
por: Ding, Xiwei, et al.
Publicado: (2016)

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells
por: Bazzazi, Hojjat, et al.
Publicado: (2017)

Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR/SphK1 crosstalk
por: Schiefler, Carlotta, et al.
Publicado: (2014)

SphK2 over-expression promotes osteosarcoma cell growth
por: Xu, Dawei, et al.
Publicado: (2017)

Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation
por: Dai, Lan, et al.
Publicado: (2022)

Effects of Inhibition of Serine Palmitoyltransferase (SPT) and Sphingosine Kinase 1 (SphK1) on Palmitate Induced Insulin Resistance in L6 Myotubes
por: Mikłosz, Agnieszka, et al.
Publicado: (2013)

Targeting SphK2 Reverses Acquired Resistance of Regorafenib in Hepatocellular Carcinoma
por: Shi, Weiwei, et al.
Publicado: (2020)

SphK1‐driven autophagy potentiates focal adhesion paxillin‐mediated metastasis in colorectal cancer
por: Wu, Jiang‐Ni, et al.
Publicado: (2021)

MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2
por: Xiao, Geqiong, et al.
Publicado: (2018)

Triple Negative Breast Cancer Depends on Sphingosine Kinase 1 (SphK1)/Sphingosine-1-Phosphate (S1P)/Sphingosine 1-Phosphate Receptor 3 (S1PR3)/Notch Signaling for Metastasis
por: Wang, Shushu, et al.
Publicado: (2018)

Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation
por: Dai, Lan, et al.
Publicado: (2021)

Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth
por: Jin, Lu, et al.
Publicado: (2023)

Sphingosine kinase 2 inhibitor ABC294640 suppresses neuronal excitability and inhibits multiple endogenously and exogenously expressed voltage-gated ion channels in cultured cells
por: Zhang, Fei, et al.
Publicado: (2020)

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
por: Lee, Ju Youn, et al.
Publicado: (2018)

Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons
por: Lee, Hyun, et al.
Publicado: (2014)

Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells
por: McNaughton, Melissa, et al.
Publicado: (2016)

The therapeutic value of the SphK1-targeting microRNA-3677 in human osteosarcoma cells
por: Yao, Chen, et al.
Publicado: (2020)

β-Caryophyllene from Chilli Pepper Inhibits the Proliferation of Non-Small Cell Lung Cancer Cells by Affecting miR-659-3p-Targeted Sphingosine Kinase 1 (SphK1)
por: Lei, Jiaji, et al.
Publicado: (2021)

Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1
por: Vettorazzi, Sabine, et al.
Publicado: (2015)

Spatiotemporal Expression of SphK1 and S1PR2 in the Hippocampus of Pilocarpine Rat Model and the Epileptic Foci of Temporal Lobe Epilepsy
por: Dong, Yuan-Yuan, et al.
Publicado: (2020)

MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2
por: Qiu, Wangwang, et al.
Publicado: (2016)

Dabigatran Suppresses PAR-1/SphK/S1P Activation of Astrocytes in Experimental Autoimmune Encephalomyelitis Model
por: Chen, Rong, et al.
Publicado: (2020)

MiR-124 inhibits the migration and invasion of ovarian cancer cells by targeting SphK1
por: Zhang, Hanwen, et al.
Publicado: (2013)

Activation of the SphK1/ERK/p-ERK pathway promotes autophagy in colon cancer cells
por: Xu, Chunyan, et al.
Publicado: (2018)

Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19
por: McGowan, Eileen M, et al.
Publicado: (2020)

The combination of a sphingosine kinase 2 inhibitor (ABC294640) and a Bcl‐2 inhibitor (ABT‐199) displays synergistic anti‐myeloma effects in myeloma cells without a t(11;14) translocation
por: Sundaramoorthy, Pasupathi, et al.
Publicado: (2018)

Effect of the Interaction between Viral PB2 and Host SphK1 on H9N2 AIV Replication in Mammals
por: Zhou, Yong, et al.
Publicado: (2022)

Correction: MicroRNA-613 inhibits cell growth, migration and invasion of papillary thyroid carcinoma by regulating SphK2
por: Qiu, Wangwang, et al.
Publicado: (2022)

The Sphingosine Kinase 2 Inhibitor ABC294640 Restores the Sensitivity of BRAFV600E Mutant Colon Cancer Cells to Vemurafenib by Reducing AKT-Mediated Expression of Nucleophosmin and Translationally-Controlled Tumour Protein
por: Grbčić, Petra, et al.
Publicado: (2021)

SphK1-targeted miR-6784 inhibits functions of skin squamous cell carcinoma cells
por: Gong, Zhen-Hua, et al.
Publicado: (2021)

Inhibition of SphK1/S1P Signaling Pathway Alleviates Fibrosis and Inflammation of Rat Myocardium after Myocardial Infarction
por: Wu, Xiaokui, et al.
Publicado: (2022)

An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma
por: Pan, Jian, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_kfpjiki103ah4b44hvs133ng2o