Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

The PLA2G6 gene encodes a group VIA calcium-independent phospholipase A2 beta enzyme that selectively hydrolyses glycerophospholipids to release free fatty acids. Mutations in PLA2G6 have been associated with disorders such as infantile neuroaxonal dystrophy, neurodegeneration with brain iron accumu...

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Detalles Bibliográficos
Autores principales: Kinghorn, Kerri J., Castillo-Quan, Jorge Iván, Bartolome, Fernando, Angelova, Plamena R., Li, Li, Pope, Simon, Cochemé, Helena M., Khan, Shabana, Asghari, Shabnam, Bhatia, Kailash P., Hardy, John, Abramov, Andrey Y., Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559908/
https://www.ncbi.nlm.nih.gov/pubmed/26001724
http://dx.doi.org/10.1093/brain/awv132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559908/
https://www.ncbi.nlm.nih.gov/pubmed/26001724
http://dx.doi.org/10.1093/brain/awv132

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