Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice

INTRODUCTION: Substantial data has shown that the lectican group of chondroitin sulfate proteoglycans are involved in inhibition of axonal plasticity in response to injury in the central nervous system. Increasing evidence indicates that lecticans may also play a role in synaptic plasticity related...

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Detalles Bibliográficos
Autores principales: Howell, Matthew D., Bailey, Lauren A., Cozart, Michael A., Gannon, Brenda M., Gottschall, Paul E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559967/
https://www.ncbi.nlm.nih.gov/pubmed/26337292
http://dx.doi.org/10.1186/s40478-015-0233-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559967/
https://www.ncbi.nlm.nih.gov/pubmed/26337292
http://dx.doi.org/10.1186/s40478-015-0233-z

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