Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6
Cerebral aneurysms are well known to be associated with cardiac myxomas. The mechanism of cerebral aneurysm formation remains to be elucidated. Embolization of tumor particles in the vessel wall has been proposed as the likely mechanism for aneurysm formation. Recent reports suggest interleukin-6 (I...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560324/ https://www.ncbi.nlm.nih.gov/pubmed/26351445 http://dx.doi.org/10.1159/000437256 |
_version_ | 1782388903443955712 |
---|---|
author | Ezerioha, Nnadozie Feng, Wuwei |
author_facet | Ezerioha, Nnadozie Feng, Wuwei |
author_sort | Ezerioha, Nnadozie |
collection | PubMed |
description | Cerebral aneurysms are well known to be associated with cardiac myxomas. The mechanism of cerebral aneurysm formation remains to be elucidated. Embolization of tumor particles in the vessel wall has been proposed as the likely mechanism for aneurysm formation. Recent reports suggest interleukin-6 (IL-6) may play a role as well. We describe a patient who presented with subarachnoid hemorrhage secondary to ruptured right middle cerebral artery (MCA) aneurysm and unruptured left MCA aneurysm. Subsequently, the patient was found to have an atrial myxoma and persistently elevated serum IL-6 levels. Transcranial Doppler monitoring showed multiple emboli in the right MCA vascular territory on day 1 after surgery but no recurrent embolization during the next 2 weeks on repeated tests. Elevated IL-6 levels were noted both on day 1 and on day 30. Our findings provide evidence that IL-6 elevation and not tumor embolization is likely the culprit for aneurysm formation in some patients with atrial myxoma. |
format | Online Article Text |
id | pubmed-4560324 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-45603242015-09-08 Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 Ezerioha, Nnadozie Feng, Wuwei Case Rep Neurol Published online: July, 2015 Cerebral aneurysms are well known to be associated with cardiac myxomas. The mechanism of cerebral aneurysm formation remains to be elucidated. Embolization of tumor particles in the vessel wall has been proposed as the likely mechanism for aneurysm formation. Recent reports suggest interleukin-6 (IL-6) may play a role as well. We describe a patient who presented with subarachnoid hemorrhage secondary to ruptured right middle cerebral artery (MCA) aneurysm and unruptured left MCA aneurysm. Subsequently, the patient was found to have an atrial myxoma and persistently elevated serum IL-6 levels. Transcranial Doppler monitoring showed multiple emboli in the right MCA vascular territory on day 1 after surgery but no recurrent embolization during the next 2 weeks on repeated tests. Elevated IL-6 levels were noted both on day 1 and on day 30. Our findings provide evidence that IL-6 elevation and not tumor embolization is likely the culprit for aneurysm formation in some patients with atrial myxoma. S. Karger AG 2015-07-21 /pmc/articles/PMC4560324/ /pubmed/26351445 http://dx.doi.org/10.1159/000437256 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. |
spellingShingle | Published online: July, 2015 Ezerioha, Nnadozie Feng, Wuwei Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title | Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_full | Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_fullStr | Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_full_unstemmed | Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_short | Intracardiac Myxoma, Cerebral Aneurysms and Elevated Interleukin-6 |
title_sort | intracardiac myxoma, cerebral aneurysms and elevated interleukin-6 |
topic | Published online: July, 2015 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560324/ https://www.ncbi.nlm.nih.gov/pubmed/26351445 http://dx.doi.org/10.1159/000437256 |
work_keys_str_mv | AT ezeriohannadozie intracardiacmyxomacerebralaneurysmsandelevatedinterleukin6 AT fengwuwei intracardiacmyxomacerebralaneurysmsandelevatedinterleukin6 |