Exploring Strong Interactions in Proteins with Quantum Chemistry and Examples of Their Applications in Drug Design

OBJECTIVES: Three strong interactions between amino acid side chains (salt bridge, cation-π, and amide bridge) are studied that are stronger than (or comparable to) the common hydrogen bond interactions, and play important roles in protein-protein interactions. METHODS: Quantum chemical methods MP2...

Descripción completa

Detalles Bibliográficos
Autores principales: Xie, Neng-Zhong, Du, Qi-Shi, Li, Jian-Xiu, Huang, Ri-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560430/
https://www.ncbi.nlm.nih.gov/pubmed/26339784
http://dx.doi.org/10.1371/journal.pone.0137113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560430/
https://www.ncbi.nlm.nih.gov/pubmed/26339784
http://dx.doi.org/10.1371/journal.pone.0137113

Ejemplares similares