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CXCR4 in breast cancer: oncogenic role and therapeutic targeting

Chemokines are 8–12 kDa peptides that function as chemoattractant cytokines and are involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled seven-span transmembrane receptors. Chemokines play a fundamental role in the regulation of a variety of ce...

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Autores principales: Xu, Chao, Zhao, Hong, Chen, Haitao, Yao, Qinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560524/
https://www.ncbi.nlm.nih.gov/pubmed/26356032
http://dx.doi.org/10.2147/DDDT.S84932
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author Xu, Chao
Zhao, Hong
Chen, Haitao
Yao, Qinghua
author_facet Xu, Chao
Zhao, Hong
Chen, Haitao
Yao, Qinghua
author_sort Xu, Chao
collection PubMed
description Chemokines are 8–12 kDa peptides that function as chemoattractant cytokines and are involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled seven-span transmembrane receptors. Chemokines play a fundamental role in the regulation of a variety of cellular, physiological, and developmental processes. Their aberrant expression can lead to a variety of human diseases including cancer. C-X-C chemokine receptor type 4 (CXCR4), also known as fusin or CD184, is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12). CXCR4 belongs to the superfamily of the seven transmembrane domain heterotrimeric G protein-coupled receptors and is functionally expressed on the cell surface of various types of cancer cells. CXCR4 also plays a role in the cell proliferation and migration of these cells. Recently, CXCR4 has been reported to play an important role in cell survival, proliferation, migration, as well as metastasis of several cancers including breast cancer. This review is mainly focused on the current knowledge of the oncogenic role and potential drugs that target CXCR4 in breast cancer. Additionally, CXCR4 proangiogenic molecular mechanisms will be reviewed. Strict biunivocal binding affinity and activation of CXCR4/CXCL12 complex make CXCR4 a unique molecular target for prevention and treatment of breast cancer.
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spelling pubmed-45605242015-09-09 CXCR4 in breast cancer: oncogenic role and therapeutic targeting Xu, Chao Zhao, Hong Chen, Haitao Yao, Qinghua Drug Des Devel Ther Review Chemokines are 8–12 kDa peptides that function as chemoattractant cytokines and are involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled seven-span transmembrane receptors. Chemokines play a fundamental role in the regulation of a variety of cellular, physiological, and developmental processes. Their aberrant expression can lead to a variety of human diseases including cancer. C-X-C chemokine receptor type 4 (CXCR4), also known as fusin or CD184, is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12). CXCR4 belongs to the superfamily of the seven transmembrane domain heterotrimeric G protein-coupled receptors and is functionally expressed on the cell surface of various types of cancer cells. CXCR4 also plays a role in the cell proliferation and migration of these cells. Recently, CXCR4 has been reported to play an important role in cell survival, proliferation, migration, as well as metastasis of several cancers including breast cancer. This review is mainly focused on the current knowledge of the oncogenic role and potential drugs that target CXCR4 in breast cancer. Additionally, CXCR4 proangiogenic molecular mechanisms will be reviewed. Strict biunivocal binding affinity and activation of CXCR4/CXCL12 complex make CXCR4 a unique molecular target for prevention and treatment of breast cancer. Dove Medical Press 2015-08-28 /pmc/articles/PMC4560524/ /pubmed/26356032 http://dx.doi.org/10.2147/DDDT.S84932 Text en © 2015 Xu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Xu, Chao
Zhao, Hong
Chen, Haitao
Yao, Qinghua
CXCR4 in breast cancer: oncogenic role and therapeutic targeting
title CXCR4 in breast cancer: oncogenic role and therapeutic targeting
title_full CXCR4 in breast cancer: oncogenic role and therapeutic targeting
title_fullStr CXCR4 in breast cancer: oncogenic role and therapeutic targeting
title_full_unstemmed CXCR4 in breast cancer: oncogenic role and therapeutic targeting
title_short CXCR4 in breast cancer: oncogenic role and therapeutic targeting
title_sort cxcr4 in breast cancer: oncogenic role and therapeutic targeting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560524/
https://www.ncbi.nlm.nih.gov/pubmed/26356032
http://dx.doi.org/10.2147/DDDT.S84932
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