Recruitment and activation of the ATM kinase in the absence of DNA damage sensors

Two kinases, ATM and DNA-PKcs, control rapid responses to DNA double-strand breaks (DSBs). The paradigm for ATM control is recruitment and activation by the Mre11–Rad50–NBS1 (MRN) sensor complex, whereas DNA-PKcs requires the sensor Ku (Ku70–Ku80). Using Mus musculus cells harboring targeted mutant...

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Detalles Bibliográficos
Autores principales: Hartlerode, Andrea J., Morgan, Mary J., Wu, Yipin, Buis, Jeffrey, Ferguson, David O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560612/
https://www.ncbi.nlm.nih.gov/pubmed/26280532
http://dx.doi.org/10.1038/nsmb.3072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560612/
https://www.ncbi.nlm.nih.gov/pubmed/26280532
http://dx.doi.org/10.1038/nsmb.3072

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