Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode

Autocatalytic phosphorylation of receptor tyrosine kinases (RTKs) enables diverse, context-dependent responses to extracellular signals but comes at the price of autonomous, ligand-independent activation. Using a conformational biosensor that reports on the kinase activity of the cell guidance ephri...

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Detalles Bibliográficos
Autores principales: Sabet, Ola, Stockert, Rabea, Xouri, Georgia, Brüggemann, Yannick, Stanoev, Angel, Bastiaens, Philippe I. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560775/
https://www.ncbi.nlm.nih.gov/pubmed/26292967
http://dx.doi.org/10.1038/ncomms9047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560775/
https://www.ncbi.nlm.nih.gov/pubmed/26292967
http://dx.doi.org/10.1038/ncomms9047

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