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Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode
Autocatalytic phosphorylation of receptor tyrosine kinases (RTKs) enables diverse, context-dependent responses to extracellular signals but comes at the price of autonomous, ligand-independent activation. Using a conformational biosensor that reports on the kinase activity of the cell guidance ephri...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560775/ https://www.ncbi.nlm.nih.gov/pubmed/26292967 http://dx.doi.org/10.1038/ncomms9047 |