Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

The generation of induced pluripotent stem cells (iPSC) from adult somatic cells is one of the most remarkable discoveries in recent decades. However, several works have reported evidence of genomic instability in iPSC, raising concerns on their biomedical use. The reasons behind the genomic instabi...

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Detalles Bibliográficos
Autores principales: Ruiz, Sergio, Lopez-Contreras, Andres J., Gabut, Mathieu, Marion, Rosa M., Gutierrez-Martinez, Paula, Bua, Sabela, Ramirez, Oscar, Olalde, Iñigo, Rodrigo-Perez, Sara, Li, Han, Marques-Bonet, Tomas, Serrano, Manuel, Blasco, Maria A., Batada, Nizar N., Fernandez-Capetillo, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560784/
https://www.ncbi.nlm.nih.gov/pubmed/26292731
http://dx.doi.org/10.1038/ncomms9036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560784/
https://www.ncbi.nlm.nih.gov/pubmed/26292731
http://dx.doi.org/10.1038/ncomms9036

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