Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)

Intrinsically disordered proteins can phase separate from the soluble intracellular space, and tend to aggregate under pathological conditions. The physiological functions and molecular triggers of liquid demixing by phase separation are not well understood. Here we show in vitro and in vivo that th...

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Detalles Bibliográficos
Autores principales: Altmeyer, Matthias, Neelsen, Kai J., Teloni, Federico, Pozdnyakova, Irina, Pellegrino, Stefania, Grøfte, Merete, Rask, Maj-Britt Druedahl, Streicher, Werner, Jungmichel, Stephanie, Nielsen, Michael Lund, Lukas, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560800/
https://www.ncbi.nlm.nih.gov/pubmed/26286827
http://dx.doi.org/10.1038/ncomms9088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560800/
https://www.ncbi.nlm.nih.gov/pubmed/26286827
http://dx.doi.org/10.1038/ncomms9088

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