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Dual-topology insertion of a dual-topology membrane protein

Some membrane transporters are dual-topology dimers in which the subunits have inverted transmembrane topology. How a cell manages to generate equal populations of two opposite topologies from the same polypeptide chain remains unclear. For the dual-topology transporter EmrE, the evidence to date re...

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Detalles Bibliográficos
Autores principales: Woodall, Nicholas B., Yin, Ying, Bowie, James U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560821/
https://www.ncbi.nlm.nih.gov/pubmed/26306475
http://dx.doi.org/10.1038/ncomms9099