Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain

Hyaluronan (HA) is present in the extracellular matrix of all body tissues, including synovial fluid in joints, in which it behaves as a filter that buffers transmission of mechanical forces to nociceptor nerve endings thereby reducing pain. Using recombinant systems, mouse-cultured dorsal root gang...

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Detalles Bibliográficos
Autores principales: Caires, Rebeca, Luis, Enoch, Taberner, Francisco J., Fernandez-Ballester, Gregorio, Ferrer-Montiel, Antonio, Balazs, Endre A., Gomis, Ana, Belmonte, Carlos, de la Peña, Elvira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560824/
https://www.ncbi.nlm.nih.gov/pubmed/26311398
http://dx.doi.org/10.1038/ncomms9095