Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis

BACKGROUND & AIMS: Little is known about the pathogenic mechanisms of chronic pancreatitis. We investigated the roles of complement component 5 (C5) in pancreatic fibrogenesis in mice and patients. METHODS: Chronic pancreatitis was induced by ligation of the midpancreatic duct, followed by a sin...

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Detalles Bibliográficos
Autores principales: Sendler, Matthias, Beyer, Georg, Mahajan, Ujjwal M., Kauschke, Vivien, Maertin, Sandrina, Schurmann, Claudia, Homuth, Georg, Völker, Uwe, Völzke, Henry, Halangk, Walter, Wartmann, Thomas, Weiss, Frank-Ulrich, Hegyi, Peter, Lerch, Markus M., Mayerle, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560830/
https://www.ncbi.nlm.nih.gov/pubmed/26001927
http://dx.doi.org/10.1053/j.gastro.2015.05.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560830/
https://www.ncbi.nlm.nih.gov/pubmed/26001927
http://dx.doi.org/10.1053/j.gastro.2015.05.012

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