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Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis

BACKGROUND & AIMS: Little is known about the pathogenic mechanisms of chronic pancreatitis. We investigated the roles of complement component 5 (C5) in pancreatic fibrogenesis in mice and patients. METHODS: Chronic pancreatitis was induced by ligation of the midpancreatic duct, followed by a sin...

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Detalles Bibliográficos
Autores principales:	Sendler, Matthias, Beyer, Georg, Mahajan, Ujjwal M., Kauschke, Vivien, Maertin, Sandrina, Schurmann, Claudia, Homuth, Georg, Völker, Uwe, Völzke, Henry, Halangk, Walter, Wartmann, Thomas, Weiss, Frank-Ulrich, Hegyi, Peter, Lerch, Markus M., Mayerle, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	W.B. Saunders 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560830/ https://www.ncbi.nlm.nih.gov/pubmed/26001927 http://dx.doi.org/10.1053/j.gastro.2015.05.012

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