PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

Cholesterol biosynthesis is regulated by transcription factors SREBPs and their escort protein Scap. On sterol depletion, Scap/SREBP complex is transported from endoplasmic reticulum (ER) to the Golgi apparatus where SREBP is activated. Under cholesterol sufficient condition, Insigs act as anchor pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Daqian, Wang, Zheng, Zhang, Yuxue, Jiang, Wei, Pan, Yi, Song, Bao-Liang, Chen, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560833/
https://www.ncbi.nlm.nih.gov/pubmed/26311497
http://dx.doi.org/10.1038/ncomms9100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560833/
https://www.ncbi.nlm.nih.gov/pubmed/26311497
http://dx.doi.org/10.1038/ncomms9100

Ejemplares similares