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PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

Cholesterol biosynthesis is regulated by transcription factors SREBPs and their escort protein Scap. On sterol depletion, Scap/SREBP complex is transported from endoplasmic reticulum (ER) to the Golgi apparatus where SREBP is activated. Under cholesterol sufficient condition, Insigs act as anchor pr...

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Detalles Bibliográficos
Autores principales:	Xu, Daqian, Wang, Zheng, Zhang, Yuxue, Jiang, Wei, Pan, Yi, Song, Bao-Liang, Chen, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560833/ https://www.ncbi.nlm.nih.gov/pubmed/26311497 http://dx.doi.org/10.1038/ncomms9100

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