X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells

X chromosome inactivation (XCI) is the dosage compensation mechanism that evolved in female mammals to correct the genetic imbalance of X-linked genes between sexes. X chromosome inactivation occurs in early development when one of the two X chromosomes of females is nearly-completely silenced. Diff...

Descripción completa

Detalles Bibliográficos
Autores principales: Pintacuda, Greta, Cerase, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561061/
https://www.ncbi.nlm.nih.gov/pubmed/26198263
http://dx.doi.org/10.1007/s12015-015-9597-5
_version_ 1782388987758903296
author Pintacuda, Greta
Cerase, Andrea
author_facet Pintacuda, Greta
Cerase, Andrea
author_sort Pintacuda, Greta
collection PubMed
description X chromosome inactivation (XCI) is the dosage compensation mechanism that evolved in female mammals to correct the genetic imbalance of X-linked genes between sexes. X chromosome inactivation occurs in early development when one of the two X chromosomes of females is nearly-completely silenced. Differentiating Embryonic Stem cells (ESC) are regarded as a useful tool to study XCI, since they recapitulate many events occurring during early development. In this review we aim to summarise the advances in the field and to discuss the close connection between cell differentiation and X chromosome inactivation, with a particular focus on mouse ESCs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12015-015-9597-5) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-4561061
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-45610612015-09-11 X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells Pintacuda, Greta Cerase, Andrea Stem Cell Rev Article X chromosome inactivation (XCI) is the dosage compensation mechanism that evolved in female mammals to correct the genetic imbalance of X-linked genes between sexes. X chromosome inactivation occurs in early development when one of the two X chromosomes of females is nearly-completely silenced. Differentiating Embryonic Stem cells (ESC) are regarded as a useful tool to study XCI, since they recapitulate many events occurring during early development. In this review we aim to summarise the advances in the field and to discuss the close connection between cell differentiation and X chromosome inactivation, with a particular focus on mouse ESCs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12015-015-9597-5) contains supplementary material, which is available to authorized users. Springer US 2015-07-22 2015 /pmc/articles/PMC4561061/ /pubmed/26198263 http://dx.doi.org/10.1007/s12015-015-9597-5 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Pintacuda, Greta
Cerase, Andrea
X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells
title X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells
title_full X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells
title_fullStr X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells
title_full_unstemmed X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells
title_short X Inactivation Lessons from Differentiating Mouse Embryonic Stem Cells
title_sort x inactivation lessons from differentiating mouse embryonic stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561061/
https://www.ncbi.nlm.nih.gov/pubmed/26198263
http://dx.doi.org/10.1007/s12015-015-9597-5
work_keys_str_mv AT pintacudagreta xinactivationlessonsfromdifferentiatingmouseembryonicstemcells
AT ceraseandrea xinactivationlessonsfromdifferentiatingmouseembryonicstemcells

Ejemplares similares