Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction

Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system. In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown. However, the relationship between ApoE gene polymorphism and severity of CAD...

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Autores principales: Karahan, Zülküf, Uğurlu, Murat, Uçaman, Berzal, Uluğ, Ali Veysel, Kaya, İlyas, Çevik, Kemal, Öztürk, Önder, Iyem, Hikmet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561336/
https://www.ncbi.nlm.nih.gov/pubmed/26380146
http://dx.doi.org/10.1155/2015/363458
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author Karahan, Zülküf
Uğurlu, Murat
Uçaman, Berzal
Uluğ, Ali Veysel
Kaya, İlyas
Çevik, Kemal
Öztürk, Önder
Iyem, Hikmet
author_facet Karahan, Zülküf
Uğurlu, Murat
Uçaman, Berzal
Uluğ, Ali Veysel
Kaya, İlyas
Çevik, Kemal
Öztürk, Önder
Iyem, Hikmet
author_sort Karahan, Zülküf
collection PubMed
description Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system. In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown. However, the relationship between ApoE gene polymorphism and severity of CAD in patients with acute myocardial infarction (MI) has not been well known. The aim of this study is to investigate the relation between ApoE polymorphism and severity of CAD in patients with acute MI by using the Gensini Score. In this study, 138 patients were admitted to cardiology clinic with diagnosis of acute MI, and angiographic assessment was performed using the Gensini Score. Blood samples were obtained from all patients in the first day. The patients with ApoE34 genotype had high Gensini scores. Besides, the patients with E4 allele carriers were associated with high Gensini score compared with the patients without E4 allele carriers (p:0,22). The patients with E4 allele carriers were associated with higher LDL cholesterol and total cholesterol compared with the patients without E4 allele carriers (p:0,001 and p:0,03, resp.). There were no statistically significant differences between ApoE genotypes and severity of CAD by using the Gensini Score. But, the patients with E4 allele carriers were associated with high lipid levels.
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spelling pubmed-45613362015-09-14 Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction Karahan, Zülküf Uğurlu, Murat Uçaman, Berzal Uluğ, Ali Veysel Kaya, İlyas Çevik, Kemal Öztürk, Önder Iyem, Hikmet Cardiol Res Pract Research Article Apolipoprotein E (ApoE) is a plasma protein and associated with cholesterol transport system. In several studies, the relationship between ApoE gene polymorphism and severity of coronary artery disease (CAD) has been shown. However, the relationship between ApoE gene polymorphism and severity of CAD in patients with acute myocardial infarction (MI) has not been well known. The aim of this study is to investigate the relation between ApoE polymorphism and severity of CAD in patients with acute MI by using the Gensini Score. In this study, 138 patients were admitted to cardiology clinic with diagnosis of acute MI, and angiographic assessment was performed using the Gensini Score. Blood samples were obtained from all patients in the first day. The patients with ApoE34 genotype had high Gensini scores. Besides, the patients with E4 allele carriers were associated with high Gensini score compared with the patients without E4 allele carriers (p:0,22). The patients with E4 allele carriers were associated with higher LDL cholesterol and total cholesterol compared with the patients without E4 allele carriers (p:0,001 and p:0,03, resp.). There were no statistically significant differences between ApoE genotypes and severity of CAD by using the Gensini Score. But, the patients with E4 allele carriers were associated with high lipid levels. Hindawi Publishing Corporation 2015 2015-08-24 /pmc/articles/PMC4561336/ /pubmed/26380146 http://dx.doi.org/10.1155/2015/363458 Text en Copyright © 2015 Zülküf Karahan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Karahan, Zülküf
Uğurlu, Murat
Uçaman, Berzal
Uluğ, Ali Veysel
Kaya, İlyas
Çevik, Kemal
Öztürk, Önder
Iyem, Hikmet
Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction
title Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction
title_full Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction
title_fullStr Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction
title_full_unstemmed Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction
title_short Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction
title_sort relation between apolipoprotein e gene polymorphism and severity of coronary artery disease in acute myocardial infarction
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561336/
https://www.ncbi.nlm.nih.gov/pubmed/26380146
http://dx.doi.org/10.1155/2015/363458
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