A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation

Conformation of antigen receptor gene loci spatially juxtaposes rearranging gene segments in the appropriate cell lineage and developmental stage. We describe a three-step pathway that establishes the structure of the 2.8-Mb immunoglobulin heavy chain gene (IgH) locus in pro-B cells. Each step uses...

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Detalles Bibliográficos
Autores principales: Gerasimova, Tatiana, Guo, Changying, Ghosh, Amalendu, Qiu, Xiang, Montefiori, Lindsey, Verma-Gaur, Jiyoti, Choi, Nancy M., Feeney, Ann J., Sen, Ranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561478/
https://www.ncbi.nlm.nih.gov/pubmed/26302788
http://dx.doi.org/10.1101/gad.263871.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561478/
https://www.ncbi.nlm.nih.gov/pubmed/26302788
http://dx.doi.org/10.1101/gad.263871.115

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