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CRISPR adaptation biases explain preference for acquisition of foreign DNA
In the process of CRISPR adaptation, short pieces of DNA (“spacers”) are acquired from foreign elements and integrated into the CRISPR array. It so far remained a mystery how spacers are preferentially acquired from the foreign DNA while the self chromosome is avoided. Here we show that spacer acqui...
Autores principales: | Levy, Asaf, Goren, Moran G., Yosef, Ido, Auster, Oren, Manor, Miriam, Amitai, Gil, Edgar, Rotem, Qimron, Udi, Sorek, Rotem |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561520/ https://www.ncbi.nlm.nih.gov/pubmed/25874675 http://dx.doi.org/10.1038/nature14302 |
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