Atomic basis for therapeutic activation of neuronal potassium channels

Retigabine is a recently approved anticonvulsant that acts by potentiating neuronal M-current generated by KCNQ2–5 channels, interacting with a conserved Trp residue in the channel pore domain. Using unnatural amino-acid mutagenesis, we subtly altered the properties of this Trp to reveal specific ch...

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Detalles Bibliográficos
Autores principales: Kim, Robin Y., Yau, Michael C., Galpin, Jason D., Seebohm, Guiscard, Ahern, Christopher A., Pless, Stephan A., Kurata, Harley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561856/
https://www.ncbi.nlm.nih.gov/pubmed/26333338
http://dx.doi.org/10.1038/ncomms9116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561856/
https://www.ncbi.nlm.nih.gov/pubmed/26333338
http://dx.doi.org/10.1038/ncomms9116

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