A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica

The parasite Entamoeba histolytica kills human cells resulting in ulceration, inflammation and invasion of the colonic epithelium. We used the cytotoxic properties of ameba to select a genome-wide RNAi library to reveal novel host factors that control susceptibility to amebic killing. We identified...

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Detalles Bibliográficos
Autores principales: Marie, Chelsea, Verkerke, Hans P., Theodorescu, Dan, Petri, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561901/
https://www.ncbi.nlm.nih.gov/pubmed/26346926
http://dx.doi.org/10.1038/srep13613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561901/
https://www.ncbi.nlm.nih.gov/pubmed/26346926
http://dx.doi.org/10.1038/srep13613

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