Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC

Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but molecular mechanisms underlying anesthetic action remain debatable. We found that ELIC, a pLGIC from Erwinia chrysanthemi, can be functionally inhibited by isoflurane and other anesthetics. Structures of ELIC co-cr...

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Detalles Bibliográficos
Autores principales: Chen, Qiang, Kinde, Monica N., Arjunan, Palaniappa, Wells, Marta M., Cohen, Aina E., Xu, Yan, Tang, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561908/
https://www.ncbi.nlm.nih.gov/pubmed/26346220
http://dx.doi.org/10.1038/srep13833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561908/
https://www.ncbi.nlm.nih.gov/pubmed/26346220
http://dx.doi.org/10.1038/srep13833

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