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Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC

Pentameric ligand-gated ion channels (pLGICs) are targets of general anesthetics, but molecular mechanisms underlying anesthetic action remain debatable. We found that ELIC, a pLGIC from Erwinia chrysanthemi, can be functionally inhibited by isoflurane and other anesthetics. Structures of ELIC co-cr...

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Detalles Bibliográficos
Autores principales:	Chen, Qiang, Kinde, Monica N., Arjunan, Palaniappa, Wells, Marta M., Cohen, Aina E., Xu, Yan, Tang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561908/ https://www.ncbi.nlm.nih.gov/pubmed/26346220 http://dx.doi.org/10.1038/srep13833

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