Discovery of a selective, safe and novel anti-malarial compound with activity against chloroquine resistant strain of Plasmodium falciparum

In recent years the DNA minor groove has attracted much attention for the development of anti-malarial agents. In view of this we have attempted to discover novel DNA minor groove binders through in-silico and in-vitro workflow. A rigorously validated pharmacophore model comprising of two positive i...

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Detalles Bibliográficos
Autores principales: Agarwal, Ankita, Paliwal, Sarvesh, Mishra, Ruchi, Sharma, Swapnil, Kumar Dwivedi, Anil, Tripathi, Renu, Gunjan, Sarika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561909/
https://www.ncbi.nlm.nih.gov/pubmed/26346444
http://dx.doi.org/10.1038/srep13838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561909/
https://www.ncbi.nlm.nih.gov/pubmed/26346444
http://dx.doi.org/10.1038/srep13838

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