Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice

It is unclear how human apolipoprotein E4 (ApoE4) increases the risk for Alzheimer’s disease (AD). Although Aβ levels can lead to insulin signaling impairment, these experiments were done in the absence of human ApoE. To examine ApoE role, we crossed the human ApoE-targeted replacement mice with mut...

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Detalles Bibliográficos
Autores principales: Chan, Elizabeth S, Chen, Christopher, Cole, Gregory M, Wong, Boon-Seng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561911/
https://www.ncbi.nlm.nih.gov/pubmed/26346625
http://dx.doi.org/10.1038/srep13842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561911/
https://www.ncbi.nlm.nih.gov/pubmed/26346625
http://dx.doi.org/10.1038/srep13842

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