Population Pharmacokinetic Model Characterizing 24-Hour Variation in the Pharmacokinetics of Oral and Intravenous Midazolam in Healthy Volunteers

Daily rhythms in physiology may affect the pharmacokinetics of a drug. The aim of this study was to evaluate 24-hour variation in the pharmacokinetics of the CYP3A substrate midazolam. Oral (2 mg) and intravenous (1 mg) midazolam was administered at six timepoints throughout the 24-hour period in 12...

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Detalles Bibliográficos
Autores principales: van Rongen, A, Kervezee, L, Brill, MJE, van Meir, H, den Hartigh, J, Guchelaar, H-J, Meijer, JH, Burggraaf, J, van Oosterhout, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562161/
https://www.ncbi.nlm.nih.gov/pubmed/26380154
http://dx.doi.org/10.1002/psp4.12007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562161/
https://www.ncbi.nlm.nih.gov/pubmed/26380154
http://dx.doi.org/10.1002/psp4.12007

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