Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs

The organ impairment and drug–drug interaction (OI-DDI) database is the first rigorously assembled database of pharmacokinetic drug exposure data from publicly available renal and hepatic impairment studies presented together with the maximum change in drug exposure from drug interaction inhibition...

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Autores principales: Yeung, CK, Yoshida, K, Kusama, M, Zhang, H, Ragueneau-Majlessi, I, Argon, S, Li, L, Chang, P, Le, CD, Zhao, P, Zhang, L, Sugiyama, Y, Huang, S-M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Database
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562165/
https://www.ncbi.nlm.nih.gov/pubmed/26380158
http://dx.doi.org/10.1002/psp4.55
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author Yeung, CK
Yoshida, K
Kusama, M
Zhang, H
Ragueneau-Majlessi, I
Argon, S
Li, L
Chang, P
Le, CD
Zhao, P
Zhang, L
Sugiyama, Y
Huang, S-M
author_facet Yeung, CK
Yoshida, K
Kusama, M
Zhang, H
Ragueneau-Majlessi, I
Argon, S
Li, L
Chang, P
Le, CD
Zhao, P
Zhang, L
Sugiyama, Y
Huang, S-M
author_sort Yeung, CK
collection PubMed
description The organ impairment and drug–drug interaction (OI-DDI) database is the first rigorously assembled database of pharmacokinetic drug exposure data from publicly available renal and hepatic impairment studies presented together with the maximum change in drug exposure from drug interaction inhibition studies. The database was used to conduct a systematic comparison of the effect of renal/hepatic impairment and pharmacologic inhibition on drug exposure. Additional applications are feasible with the public availability of this database.
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spelling pubmed-45621652015-09-14 Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs Yeung, CK Yoshida, K Kusama, M Zhang, H Ragueneau-Majlessi, I Argon, S Li, L Chang, P Le, CD Zhao, P Zhang, L Sugiyama, Y Huang, S-M CPT Pharmacometrics Syst Pharmacol Database The organ impairment and drug–drug interaction (OI-DDI) database is the first rigorously assembled database of pharmacokinetic drug exposure data from publicly available renal and hepatic impairment studies presented together with the maximum change in drug exposure from drug interaction inhibition studies. The database was used to conduct a systematic comparison of the effect of renal/hepatic impairment and pharmacologic inhibition on drug exposure. Additional applications are feasible with the public availability of this database. John Wiley & Sons, Ltd 2015-08 2015-07-14 /pmc/articles/PMC4562165/ /pubmed/26380158 http://dx.doi.org/10.1002/psp4.55 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Database
Yeung, CK
Yoshida, K
Kusama, M
Zhang, H
Ragueneau-Majlessi, I
Argon, S
Li, L
Chang, P
Le, CD
Zhao, P
Zhang, L
Sugiyama, Y
Huang, S-M
Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs
title Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs
title_full Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs
title_fullStr Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs
title_full_unstemmed Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs
title_short Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs
title_sort organ impairment—drug–drug interaction database: a tool for evaluating the impact of renal or hepatic impairment and pharmacologic inhibition on the systemic exposure of drugs
topic Database
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562165/
https://www.ncbi.nlm.nih.gov/pubmed/26380158
http://dx.doi.org/10.1002/psp4.55
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