Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 Status-Independent Manner

The D40 gene encodes a kinetochore protein that plays an essential role in kinetochore formation during mitosis. Short inhibitory RNA against D40, D40 siRNA, has been shown to deplete the D40 protein in the human cancer cell line HeLa, which harbors wild-type p53, and this activity was followed by t...

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Detalles Bibliográficos
Autores principales: Urata, Yuri N., Takeshita, Fumitaka, Tanaka, Hiroki, Ochiya, Takahiro, Takimoto, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562263/
https://www.ncbi.nlm.nih.gov/pubmed/26348410
http://dx.doi.org/10.1038/srep13676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562263/
https://www.ncbi.nlm.nih.gov/pubmed/26348410
http://dx.doi.org/10.1038/srep13676

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