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Stress-response balance drives the evolution of a network module and its host genome

Stress response genes and their regulators form networks that underlie drug resistance. These networks often have an inherent tradeoff: their expression is costly in the absence of stress, but beneficial in stress. They can quickly emerge in the genomes of infectious microbes and cancer cells, prote...

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Detalles Bibliográficos
Autores principales: González, Caleb, Ray, Joe Christian J, Manhart, Michael, Adams, Rhys M, Nevozhay, Dmitry, Morozov, Alexandre V, Balázsi, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562500/
https://www.ncbi.nlm.nih.gov/pubmed/26324468
http://dx.doi.org/10.15252/msb.20156185