Stretch-induced increase in cardiac contractility is independent of myocyte Ca(2+) while block of stretch channels by streptomycin improves contractility after ischemic stunning

Stretching the cardiac left ventricle (LV) enhances contractility but its effect on myoplasmic [Ca(2+)] is controversial. We measured LV pressure (LVP) and [Ca(2+)] as a function of intra-LV stretch in guinea pig intact hearts before and after 15 min global stunning ± perfusion with streptomycin (ST...

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Detalles Bibliográficos
Autores principales: Rhodes, Samhita S, Camara, Amadou K S, Aldakkak, Mohammed, Heisner, James S, Stowe, David F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562572/
https://www.ncbi.nlm.nih.gov/pubmed/26290532
http://dx.doi.org/10.14814/phy2.12486

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