Cargando…

Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells

AIMS/HYPOTHESIS: The adipose tissue-derived hormone leptin plays an important role in the maintenance of body weight and glucose homeostasis. Leptin mediates its effects by interaction with leptin receptors (LepRb), which are highly expressed in the hypothalamus and other brain centres, and at lower...

Descripción completa

Detalles Bibliográficos
Autores principales:	Soedling, Helen, Hodson, David J., Adrianssens, Alice E., Gribble, Fiona M., Reimann, Frank, Trapp, Stefan, Rutter, Guy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Original article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563029/ https://www.ncbi.nlm.nih.gov/pubmed/26413468 http://dx.doi.org/10.1016/j.molmet.2015.06.007

Ejemplares similares

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance
por: Sayers, Sophie R., et al.
Publicado: (2016)

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice
por: Zac-Varghese, Sagen, et al.
Publicado: (2014)

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius: Electrical Properties of Glucagon-Like Peptide 1 Neurons
por: Hisadome, Kazunari, et al.
Publicado: (2010)

Heterogeneity of glucagonomas due to differential processing of proglucagon-derived peptides
por: Challis, Benjamin G, et al.
Publicado: (2015)

Leptin therapy, insulin sensitivity, and glucose homeostasis
por: Paz-Filho, Gilberto, et al.
Publicado: (2012)

Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine
por: Glass, Leslie L., et al.
Publicado: (2017)

Variation in the Evolution and Sequences of Proglucagon and the Receptors for Proglucagon-Derived Peptides in Mammals
por: Irwin, David M.
Publicado: (2021)

Editorial: Proglucagon-Derived Peptides
por: Flatt, Peter R., et al.
Publicado: (2021)

Proglucagon-Derived Peptides as Therapeutics
por: Lafferty, Ryan A., et al.
Publicado: (2021)

The role of leptin in glucose homeostasis
por: Denroche, Heather C, et al.
Publicado: (2012)

The Wnt Signaling Pathway Effector TCF7L2 Controls Gut and Brain Proglucagon Gene Expression and Glucose Homeostasis
por: Shao, Weijuan, et al.
Publicado: (2013)

Mutational Landscape of the Proglucagon-Derived Peptides
por: Lindquist, Peter, et al.
Publicado: (2021)

CCK Stimulation of GLP-1 Neurons Involves α(1)-Adrenoceptor–Mediated Increase in Glutamatergic Synaptic Inputs
por: Hisadome, Kazunari, et al.
Publicado: (2011)

Mechanisms underlying glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 secretion
por: Reimann, Frank, et al.
Publicado: (2016)

Insights on glicentin, a promising peptide of the proglucagon family
por: Raffort, Juliette, et al.
Publicado: (2017)

Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity
por: Holst, Jens Juul
Publicado: (2022)

Remote control of glucose homeostasis in vivo using photopharmacology
por: Mehta, Zenobia B., et al.
Publicado: (2017)

Effect of Konjac Mannan Oligosaccharides on Glucose Homeostasis via the Improvement of Insulin and Leptin Resistance In Vitro and In Vivo
por: Zhu, Di, et al.
Publicado: (2019)

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production
por: Semplici, Francesca, et al.
Publicado: (2016)

Hypothalamic arcuate nucleus glucokinase regulates insulin secretion and glucose homeostasis
por: Ma, Yue, et al.
Publicado: (2018)

A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1
por: Thiebaud, Nicolas, et al.
Publicado: (2019)

The role of leptin in the control of insulin-glucose axis
por: Amitani, Marie, et al.
Publicado: (2013)

Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides
por: Takano, Yuko, et al.
Publicado: (2015)

MON-591 Effect of Liraglutide Treatment on Proglucagon-Derived Peptides
por: Kim, Sun, et al.
Publicado: (2020)

The Enigmatic N-Terminal Domain of Proglucagon; A Historical Perspective
por: Conlon, J. Michael
Publicado: (2021)

Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health
por: Wagner, Robert, et al.
Publicado: (2022)

Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity
por: Takagi, Yusuke, et al.
Publicado: (2015)

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes–Associated Variants
por: Nicolson, Tamara J., et al.
Publicado: (2009)

Characterization of proinsulin- and proglucagon-converting activities in isolated islet secretory granules
Publicado: (1981)

Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides
por: Watanabe, Chika, et al.
Publicado: (2012)

Glucose Sensing in L Cells: A Primary Cell Study
por: Reimann, Frank, et al.
Publicado: (2008)

Neurochemical Characterization of Body Weight-Regulating Leptin Receptor Neurons in the Nucleus of the Solitary Tract
por: Garfield, Alastair S., et al.
Publicado: (2012)

Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides
por: Fukami, Ayako, et al.
Publicado: (2013)

Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin
por: Iida, Atsushi, et al.
Publicado: (2016)

Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse
por: Holt, Marie K., et al.
Publicado: (2017)

GLP-1 Localisation and Proglucagon Gene Expression in Healthy and Diabetic Mouse Ileum
por: Taşçı, Serap Koral, et al.
Publicado: (2018)

Proglucagon-Derived Peptides Expression and Secretion in Rat Insulinoma INS-1 Cells
por: Acosta-Montalvo, Ana, et al.
Publicado: (2020)

Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis
por: Thon, Mina, et al.
Publicado: (2016)

Galectin-3 gene deletion results in defective adipose tissue maturation and impaired insulin sensitivity and glucose homeostasis
por: Blasetti Fantauzzi, Claudia, et al.
Publicado: (2020)

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery
por: Larraufie, Pierre, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0ngn1anrrcbi255uonvq6kfb2b