Cargando…
Trastuzumab Induces an Immediate, Transient Volume Increase in Humans: A Randomised Placebo-Controlled Trial
BACKGROUND: The exact extent of and the mechanism by which trastuzumab causes cardiac side effects are not completely unravelled. We investigated the (cardiotoxic) side effects of trastuzumab in a relatively large homogeneous population. METHODS: Healthy male volunteers (n = 54) with a left ventricl...
Autores principales: | Reijers, Joannes A.A., Burggraaf, Jacobus |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563119/ https://www.ncbi.nlm.nih.gov/pubmed/26425703 http://dx.doi.org/10.1016/j.ebiom.2015.05.002 |
Ejemplares similares
-
Remarkable Pharmacokinetics of Monoclonal Antibodies: A Quest for an Explanation
por: Reijers, Joannes A. A., et al.
Publicado: (2016) -
Potential Influence of Endothelial Adsorption on the Delayed Time to Maximum Concentration of Biopharmaceuticals
por: Reijers, Joannes A. A., et al.
Publicado: (2017) -
Adverse immunostimulation caused by impurities: The dark side of biopharmaceuticals
por: Reijers, Joannes A. A., et al.
Publicado: (2019) -
Clinical Evaluation of Humira(®) Biosimilar ONS-3010 in Healthy Volunteers: Focus on Pharmacokinetics and Pharmacodynamics
por: Dillingh, Marlous R., et al.
Publicado: (2016) -
Use of population approach non-linear mixed effects models in the evaluation of biosimilarity of monoclonal antibodies
por: Reijers, Joannes A. A., et al.
Publicado: (2016)