Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

Inhibition of de novo palmitate synthesis via fatty acid synthase (FASN) inhibition provides an unproven approach to cancer therapy with a strong biological rationale. FASN expression increases with tumor progression and associates with chemoresistance, tumor metastasis, and diminished patient survi...

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Detalles Bibliográficos
Autores principales: Ventura, Richard, Mordec, Kasia, Waszczuk, Joanna, Wang, Zhaoti, Lai, Julie, Fridlib, Marina, Buckley, Douglas, Kemble, George, Heuer, Timothy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563160/
https://www.ncbi.nlm.nih.gov/pubmed/26425687
http://dx.doi.org/10.1016/j.ebiom.2015.06.020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563160/
https://www.ncbi.nlm.nih.gov/pubmed/26425687
http://dx.doi.org/10.1016/j.ebiom.2015.06.020

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